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Phenotypes Associated with This Genotype
Genotype
MGI:3047331
Allelic
Composition		 Mybtm1Cgn/Mybtm1.1Cgn
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (56 available)
Mybtm1Cgn mutation (1 available); any Myb mutation (56 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased

immune system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased

endocrine/exocrine glands
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory