Phenotypes Associated with This Genotype

Genotype
MGI:3047247

• Allelic Composition: Tg(UAS-Shh)1Rth/0; Tg(Wnt1-GAL4)1Rth/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:57948 )

• there is a pronounced blood supply to the dorsal spinal cord

hemorrhage ( J:57948 )

• hemorrhage may be seen around the dorsal spinal cord

cellular

increased cell proliferation ( J:57948 )

• increased proliferation is seen in the spinal cord at E12.5 but not at E18.5

craniofacial

abnormal neurocranium morphology ( J:57948 )

• the membranous skull is absent

muscle

abnormal epaxial muscle morphology ( J:57948 )

• the epiaxial muscles that normally overlay the brain and spinal cord are absent

skeleton

abnormal neurocranium morphology ( J:57948 )

• the membranous skull is absent

absent vertebral arch ( J:57948 )

• the neural arches are absent

nervous system

abnormal midbrain morphology ( J:57948 )

• ventralization of the midbrain is seen by E9.5

midbrain hyperplasia ( J:57948 )

• neural hyperplasia is first detected at E9.5

• at E18.5 a tissue mass is seen emanating from the midbrain and spinal cord with a folded appearance protruding out the back of the mutants

abnormal spinal cord morphology ( J:57948 )

• at E12.5 dorsal-ventral organization of the neural precursor cells in the spinal cord is absent

hydromyelia ( J:57948 )

• between E12.5 and E18.5 expansion of the ventricular zone is seen

increased spinal cord size ( J:57948 )

• at E18.5 a tissue mass, with a folded appearance, is seen emanating from the midbrain and spinal cord and protruding out the back of the mutants

• there is a pronounced blood supply to the dorsal spinal cord

homeostasis/metabolism

hydromyelia ( J:57948 )

• between E12.5 and E18.5 expansion of the ventricular zone is seen