Phenotypes Associated with This Genotype

Genotype
MGI:3047083

• Allelic Composition: En1^{tm1(Wnt1)Wrst}/En1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:91004 )

• cell cycle length is decreased from 21.1 to 19.9 hours

increased cell proliferation ( J:91004 )

• from E11.5 to E18.5 proliferation of neural progenitors in the inferior colliculi is increased, however no change in tumor formation is seen

nervous system

increased inferior colliculus size ( J:91004 )

• the volume of the inferior colliculi is increased 4.8 fold

• this enlargement can first be detected at E13

abnormal hindbrain morphology ( J:91004 )

• there is a transient increase in the size of the lateral regions of the ventrorostral hindbrain from E10 until E15

abnormal cerebellum morphology ( J:91004 )

• enlargement of the granular cell layer resulting in a slightly undulated appearance of the rostral folia is seen in horizontal sections from adult cerebelli