mortality/aging
• mutant pups die within a few hours of birth with many of the internal organs (heart, lung, brain) appearing paler than normal however hematocrit is normal
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integument
• many large vessels clearly visible under the skin in wild-type mice can not be seen in mutants
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cardiovascular system
• many large vessels clearly visible under the skin in wild-type mice can not be seen in mutants
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• cardiac muscle cells are more transparent with a reduced cytoplasmic volume and more nuclei present compared to wild-type littermates
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muscle
• cardiac muscle cells are more transparent with a reduced cytoplasmic volume and more nuclei present compared to wild-type littermates
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• the limb musculature is less well developed
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