Phenotypes Associated with This Genotype

Genotype
MGI:3046931

• Allelic Composition: Fxr1^tm1Dln/Fxr1^tm1Dln
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91191 )

• the condition of mutants begins to deteriorate around 8 weeks of age and the average life span is only 10 - 18 weeks

behavior/neurological

decreased grip strength ( J:91191 )

• mutants are unable to support their own weight in the hanging wire grip test

abnormal gait ( J:91191 )

• walking track analysis indicates that mutants have an abnormal gait

short stride length ( J:91191 )

• mutants have a shorter stride length

cardiovascular system

disorganized myocardium ( J:91191 )

• the distinct organization of contractile filaments is significantly reduced in mutants

small heart ( J:91191 )

• at 6 weeks of age the heart is smaller than normal

endocrine/exocrine glands

small testis ( J:91191 )

♂ • at 6 weeks of age the testes are smaller than normal

growth/size/body

postnatal growth retardation ( J:91191 )

• mutant pups are the same size at birth however within a few days they are noticeably smaller than wild-type littermates

hematopoietic system

small spleen ( J:91191 )

• at 6 weeks of age the spleen is smaller than normal

immune system

small spleen ( J:91191 )

• at 6 weeks of age the spleen is smaller than normal

muscle

disorganized myocardium ( J:91191 )

• the distinct organization of contractile filaments is significantly reduced in mutants

abnormal muscle development ( J:91191 )

• at 6 weeks of age the limb musculature is less well developed

reproductive system

small testis ( J:91191 )

♂ • at 6 weeks of age the testes are smaller than normal

respiratory system

small lung ( J:91191 )

• at 6 weeks of age the lungs are smaller than normal