Phenotypes Associated with This Genotype

Genotype
MGI:3046917

• Allelic Composition: Fezf2^tm1Hibi/Fezf2^tm1Hibi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91247 )

• on a solid diet, died around 4 weeks of age

• survived when given a liquid diet

behavior/neurological

abnormal food preference ( J:91247 )

• did not eat solid food after weaning

• would continue on a liquid diet

abnormal stationary movement ( J:91247 )

• twitchy movements

hyperactivity ( J:91247 )

• moved 10X more often than normals

growth/size/body

postnatal growth retardation ( J:91247 )

• growth reduction after weaning to a solid diet

• growth normal while nursing

nervous system

abnormal telencephalon development ( J:91247 )

• boundary between cortical plate and intermediate zone irregular in lateral cortex

• reduced size of intermediate zone and fimbria/fornix

• subplate neurons failed to attract thalamocortical axons

abnormal thalamus morphology ( J:91247 )

• region containing thalamocortical axons smaller at E17.5

• reduced numbers of thalamocortical axons reaching the cortex

• some thalamocortical axons project of aberrant locations