Phenotypes for Apoe Fn1 MGI:3046828 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Fn1^tm1Bwg/Fn1^tm1Bwg
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (164 available)
Fn1^tm1Bwg mutation (1 available); any Fn1 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:90917 )

• on a high fat high cholesterol diet double homozygous mutants have reduced lesion area compared to Apoe^tm1Bres homozygotes

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:90917 )

• the cholesterol content of foam cells increases less in response to acetylated LDL compared to Apoe^tm1Bres homozygotes

decreased circulating VLDL cholesterol level ( J:90917 )

• fasting VLDL cholesterol levels after maintenance on a high fat diet are decreased compared to Apoe^tm1Bres homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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