Phenotypes Associated with This Genotype

Genotype
MGI:3046634

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre)43Smr/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

mortality/aging

neonatal lethality, complete penetrance ( J:91054 )

• died within 24 hours

behavior/neurological

abnormal suckling behavior ( J:91054 )

• difficulty suckling

craniofacial

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

limbs/digits/tail

absent hindlimb ( J:91054 )

vision/eye

eyelids open at birth ( J:91054 )

integument

increased hair follicle number ( J:91054 )

• dorsal follicle density significantly increased

growth/size/body

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars