Phenotypes Associated with This Genotype

Genotype
MGI:3046402

• Allelic Composition: Igha^tm1(Myc)Janz/Igha⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased B cell derived lymphoma incidence ( J:90901 )

• transgenic mice display an increased incidence (9.3%) of B cell derived lymphomas with a mean onset of 330 days

hematopoietic system

increased B cell apoptosis ( J:90901 )

• B cell apoptosis is increased about 4.5 fold compared to normal B cells

increased B cell proliferation ( J:90901 )

• B cells proliferate about 2.5 - 3 times faster compared to normal mice

increased plasma cell number ( J:90901 )

• B220^hiCD138⁺, putative plasmablasts, numbers are increased in the bone marrow of transgenic mice

immune system

increased B cell apoptosis ( J:90901 )

• B cell apoptosis is increased about 4.5 fold compared to normal B cells

increased B cell proliferation ( J:90901 )

• B cells proliferate about 2.5 - 3 times faster compared to normal mice

increased plasma cell number ( J:90901 )

• B220^hiCD138⁺, putative plasmablasts, numbers are increased in the bone marrow of transgenic mice

cellular

increased B cell apoptosis ( J:90901 )

• B cell apoptosis is increased about 4.5 fold compared to normal B cells

increased B cell proliferation ( J:90901 )

• B cells proliferate about 2.5 - 3 times faster compared to normal mice