Phenotypes Associated with This Genotype

Genotype
MGI:3046280

• Allelic Composition: Isl2^tm2Slp/Isl2^tm2Slp
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:89755 )

• most homozygotes die within 24 hours of birth

growth/size/body

distended abdomen ( J:89755 )

• severely distended abdomen after birth

nervous system

abnormal innervation ( J:89755 )

• bridging between segmentally arrayed motor nerves occurs

abnormal motor neuron morphology ( J:89755 )

• depletion of visceral motor neurons without an increase in somatic motor neurons

• appearance of atypical and ectopic somatic-like neurons

• small nuclei more like visceral than somatic motor neuron nuclei

abnormal neuron specification ( J:89755 )

• early stages of spinal motor neuron differentiation normal

• ectopic localization for some neurons

• tight columnar organization in thoracic region disrupted with intermingling of medial and lateral divisions