Phenotypes Associated with This Genotype

Genotype
MGI:3046106

• Allelic Composition: Gstp1/Gstp2^tm1Wolf/Gstp1/Gstp2^tm1Wolf
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:47638 )

• increased susceptibility to skin papillomas was observed upon treatment with DMBA and TPA

• papillomas appeared after 10 weeks in mutant mice, whereas none were observed in controls at this stage

• at later time points, incidence of papillomas in mutant mice was always greater than in controls

growth/size/body

increased body weight ( J:47638 )

• at six months of age, some male mice weighed in excess of 70g

integument

increased skin papilloma incidence ( J:47638 )

• increased susceptibility to skin papillomas was observed upon treatment with DMBA and TPA

• papillomas appeared after 10 weeks in mutant mice, whereas none were observed in controls at this stage

• at later time points, incidence of papillomas in mutant mice was always greater than in controls