Phenotypes Associated with This Genotype

Genotype
MGI:3046089

• Allelic Composition: a^t/a^t; Tbx15^de-H/Tbx15^de-H
• Genetic Background: involves: BTBR * C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pigmentation phenotype of the Tbx15^de-H/Tbx15^de-H a^e/a^e mouse

pigmentation

abnormal dorsoventral coat patterning ( J:87455 )

• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in a^t mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier

abnormal ventral coat pigmentation ( J:87455 )

• resembles pattern of a black-and-tan (a^t) mutation

irregular coat pigmentation ( J:87455 )

• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in a^t

craniofacial

broad nasal bridge ( J:87455 )

shortened head ( J:87455 )

• elevated skull contributes lowered ear position with pinnae projecting laterally

lowered ear position ( J:87455 )

vision/eye

ocular hypertelorism ( J:87455 )

• results in widely spaced eyes

narrow eye opening ( J:87455 )

• small palpebral fissures noted

growth/size/body

broad nasal bridge ( J:87455 )

shortened head ( J:87455 )

• elevated skull contributes lowered ear position with pinnae projecting laterally

lowered ear position ( J:87455 )

decreased body size ( J:87455 )

hearing/vestibular/ear

lowered ear position ( J:87455 )

integument

abnormal dorsoventral coat patterning ( J:87455 )

• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in a^t mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier

abnormal ventral coat pigmentation ( J:87455 )

• resembles pattern of a black-and-tan (a^t) mutation

irregular coat pigmentation ( J:87455 )

• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in a^t

respiratory system

broad nasal bridge ( J:87455 )