Phenotypes Associated with This Genotype

Genotype
MGI:3045978

• Allelic Composition: Rspo2^ftls/Rspo2^ftls
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:83881 )

• at c-section at E18, mice exhibit a gasping reflex but fail to breath and die within hours

craniofacial

cleft secondary palate ( J:83881 )

• observed in 100%

limbs/digits/tail

abnormal phalanx morphology ( J:83881 )

• loss of all or most of the distal phalanx on all formed digits

abnormal forelimb morphology ( J:83881 )

• anterior structures are missing from the right forelimb, whereas the left forelimb is typically intact

• ~50% of right forelimbs are missing anterior structures including digits 1, 2, and 3 and the radius

• 1 of 77 left forelimbs showed an absence of a skeletal element

absent radius ( J:83881 )

abnormal hindlimb morphology ( J:83881 )

• posterior structures from the autopod and zeugopod are missing with increased frequency and severity in the left hindlimb relative to the right hindlimb

absent fibula ( J:83881 )

• in some mice and sometimes accompanied by a shortening of the tibia

short tibia ( J:83881 )

• in some mice

renal/urinary system

abnormal kidney development ( J:83881 )

• bilateral supernumerary kidneys observed in some fetuses

single kidney ( J:83881 )

• unilateral absence in some fetuses

skeleton

abnormal phalanx morphology ( J:83881 )

• loss of all or most of the distal phalanx on all formed digits

absent radius ( J:83881 )

absent fibula ( J:83881 )

• in some mice and sometimes accompanied by a shortening of the tibia

short tibia ( J:83881 )

• in some mice

digestive/alimentary system

cleft secondary palate ( J:83881 )

• observed in 100%

integument

absence of all nails ( J:83881 )

• nails were absent from all formed digits

growth/size/body

cleft secondary palate ( J:83881 )

• observed in 100%