Phenotypes Associated with This Genotype

Genotype
MGI:3045966

• Allelic Composition: Srcr/Srcr⁺
• Genetic Background: BALB/c-Srcr/Cui

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:83618 )

• injection of tumor forming cells at 6 weeks of age does not result in tumor formation

• when the first injection of tumor forming cells is given at 12 or 22 weeks of age tumors form in 50% or most mutants, respectively, but then spontaneously regress

immune system

abnormal innate immunity ( J:83618 )

• mutants are able to destroy more of the tumor forming cells such that by 7 days after injection none of the injected cells are found in contrast to wild-type mice where the injected cells are the predominant cell in the peritoneal cavity

• leukocytes, mainly from the innate immune system, form rosettes and large cellular aggregates around the injected tumor forming cells these structures are not seen in wild-type mice