Phenotypes Associated with This Genotype

Genotype
MGI:3045954

• Allelic Composition: Kit^tm1Ber/Kit^tm1Ber
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:89602 )

absent coat pigmentation ( J:89602 )

• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs

white spotting ( J:89602 )

variable depigmentation ( J:89602 )

• observed in 10% to 15% of mice

• >90% of the body surface area white except around the ear

digestive/alimentary system

digestive/alimentary phenotype ( J:89602 )

N • neither stomach or intestinal distension were observed as was in Kit^{tm3Ber/tm3Ber} mice

hematopoietic system

decreased mast cell number ( J:89602 )

• reduced number of mast cells in the peritoneal cavity, and the stomach

• normal number of mast cell precursor cells and it was possible to derive mast cells from the bone marrow

immune system

immune system phenotype ( J:89602 )

N • splenomegaly was not observed, as it was in Kit^{tm3Ber/tm3Ber} mice

decreased mast cell number ( J:89602 )

• reduced number of mast cells in the peritoneal cavity, and the stomach

• normal number of mast cell precursor cells and it was possible to derive mast cells from the bone marrow

reproductive system

reproductive system phenotype ( J:89602 )

N • mice were fully fertile

integument

abnormal coat/hair pigmentation ( J:89602 )

absent coat pigmentation ( J:89602 )

• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs

white spotting ( J:89602 )

variable depigmentation ( J:89602 )

• observed in 10% to 15% of mice

• >90% of the body surface area white except around the ear