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Phenotypes Associated with This Genotype
Genotype
MGI:3045810
Allelic
Composition		 Tlr12tm1Gho/Tlr12tm1Gho
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr12tm1Gho mutation (0 available); any Tlr12 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:89754 )
• macrophages isolated from homozygous mice exhibited an impaired TNF-alpha secretion response when stimulated with uropathogenic bacteria
increased susceptibility to bacterial infection ( J:89754 )
• mice exhibit an increased susceptibility to kidney infection by uropathogenic bacteria

hematopoietic system
abnormal macrophage physiology ( J:89754 )
• macrophages isolated from homozygous mice exhibited an impaired TNF-alpha secretion response when stimulated with uropathogenic bacteria

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory