Phenotypes Associated with This Genotype

Genotype
MGI:3045797

• Allelic Composition: Pax6^tm2Pgr/Pax6^tm2Pgr; Tg(Pax6-cre,GFP)1Pgr/0
• Genetic Background: involves: FVB * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:90642 )

• most mutant pups die 3 - 6 days after birth with an overt diabetic phenotype

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:90642 )

• very few alpha cells are seen

decreased pancreatic beta cell number ( J:90642 )

• the number of insulin-expressing cells is decreased

growth/size/body

postnatal growth retardation ( J:90642 )

• 2 - 6 days after birth mutant pups develop severe growth retardation

homeostasis/metabolism

hyperglycemia ( J:90642 )

• 2 - 6 days after birth mutant pups develop hyperglycemia

decreased circulating insulin level ( J:90642 )

• 2 - 6 days after birth mutant pups develop hypoinsulinemia with insulin levels in the pancrease at 18% of normal on P1 and 6% of normal on P3

increased circulating ketone body level ( J:90642 )

• at P3 ketones are seen in all mutants with glucose levels above 20mM