Mouse Genome Informatics
involves: 129S1/Sv
phenotype observed in females
phenotype observed in males
N normal phenotype
• in the forced swim test, homozygotes are significantly more active than wild-type, particularly during the last 10 min of the test
• homozygotes appear to display less behavioral despair than wild-type littermates; whereas wild-type mice become progressively more immobile, homozygous mutants maintain the same level of activity throughout the swim test
• in the open field, homozygotes exhibit decreased exploratory activity and increased anxious-like behavior relative to wild-type
• in the elevated plus maze, homozygotes display significantly more anxiety-like behaviors with no significant changes in activity
• homozygous null males appear to be affected more than females, particularly in some measures of anxiety

Mouse Models of Human Disease
Anxiety 607834 J:51280