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Phenotypes Associated with This Genotype
Genotype
MGI:3045711
Allelic
Composition
Htr1atm1Rhn/Htr1atm1Rhn
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1atm1Rhn mutation (0 available); any Htr1a mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the forced swim test, homozygotes are significantly more active than wild-type, particularly during the last 10 min of the test
• homozygotes appear to display less behavioral despair than wild-type littermates; whereas wild-type mice become progressively more immobile, homozygous mutants maintain the same level of activity throughout the swim test
• in the open field, homozygotes exhibit decreased exploratory activity and increased anxious-like behavior relative to wild-type
• in the elevated plus maze, homozygotes display significantly more anxiety-like behaviors with no significant changes in activity
• homozygous null males appear to be affected more than females, particularly in some measures of anxiety

Mouse Models of Human Disease
OMIM ID Ref(s)
Anxiety 607834 J:51280


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory