Phenotypes Associated with This Genotype

Genotype
MGI:3045423

• Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg; Tg(Myh6-cre)2182Mds/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:90737 )

• basal glucose uptake by the heart increased 8 fold

• tendency for insulin stimulated glucose uptake by the heart to increase somewhat

abnormal lipid level ( J:90737 )

• heart uptake of VLDL decreased by 72%

decreased cardiac muscle triglyceride level ( J:90737 )

• heart content of triglycerides is decreased

increased circulating triglyceride level ( J:90737 )

• plasma triglyceride levels significantly elevated in males because of increased VLDL triglycerides

• plasma triglyceride levels in females also tended to be elevated but not significantly

• postprandial levels tended to remain elevated

increased circulating VLDL triglyceride level ( J:90737 )

decreased fatty acids level ( J:90737 )

• heart content of fatty acids is decreased

cardiovascular system

decreased cardiac muscle triglyceride level ( J:90737 )

• heart content of triglycerides is decreased

increased cardiac muscle cell glucose uptake ( J:90737 )

• basal glucose uptake by the heart increased 8-fold

• tendency for insulin stimulated glucose uptake by the heart to increase somewhat

muscle

decreased cardiac muscle triglyceride level ( J:90737 )

• heart content of triglycerides is decreased

increased cardiac muscle cell glucose uptake ( J:90737 )

• basal glucose uptake by the heart increased 8-fold

• tendency for insulin stimulated glucose uptake by the heart to increase somewhat

cellular

increased cardiac muscle cell glucose uptake ( J:90737 )

• basal glucose uptake by the heart increased 8-fold

• tendency for insulin stimulated glucose uptake by the heart to increase somewhat