About   Help   FAQ
Phenotypes Associated with This Genotype
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Jzt mutation (0 available); any Psen1 mutation (22 available)
Psen2tm1Ber mutation (0 available); any Psen2 mutation (5 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• by 10 months of age mutants have impaired performance in a novel object recognition test
• by 10 months of age some mutants show increased activity in an open field test

• a dramatic increase in apoptosis is seen in the degenerating forebrain

• by 10 months of age mutant mice start to show reduced body weights compared to wild-type

nervous system
• the lateral ventricles are immensely enlarged compared to wild-type or single knockout mice
• the third ventricle is immensely enlarged compared to wild-type or single knockout mice
• the thickness of the corpus callosum is about a third that of controls
• the thickness of the molecular layers between the CA1 pyramidal cells and dentate gyrus is significantly reduced
• the cortex is about half the normal thickness and the 6 layers can no longer be distinguished
• increased Gfap expression indicates that reactive astrogliosis occurs along with forebrain degeneration
• changes in the expression of several markers indicate that neuronal atrophy occurs along with forebrain degeneration
• degeneration is seen in the forebrain

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 4 606889 J:90685
Alzheimer Disease; AD 104300 J:90685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory