Mouse Genome Informatics
cn
    Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• exposure to environmental enrichment following contextual fear conditioning results in a significant increase in freezing responses during retention tests

cellular
• environmental enrichment induces significantly less neurogenesis in the dentate gyrus of the brain in mutants compared to wild-type controls

nervous system
• following environmental enrichment the number of newborn neurons in the subgranular zone and molecular layer of the dentate gyrus are 39% and 48% less respectively compared to wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:73252