Phenotypes Associated with This Genotype

Genotype
MGI:3045105

• Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan
• Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

white spotting ( J:23593 )

• white coat with black ears

endocrine/exocrine glands

impaired ovarian folliculogenesis ( J:23593 )

♀ • arrest at the primary follicle stage

reproductive system

reproductive system phenotype ( J:23593 )

N • no defects were observed in the postnatal testes

decreased oocyte number ( J:23593 )

♀ • reduced number of oocytes in the postnatal ovary

decreased primordial germ cell number ( J:23593 )

• progressive decrease in primordial germ cells in both females and males; ~25% that of wild-type controls at E11.5 and ~10% at E12.5

• in spite of the reduced PGC number in males, normal numbers of differentiating germ cells were observed in older males, putatively due to an increase in the mitotic proliferation of spermatogonia

impaired ovarian folliculogenesis ( J:23593 )

♀ • arrest at the primary follicle stage

female infertility ( J:23593 )

♀ • attributable to decreased numbers of oocytes

integument

white spotting ( J:23593 )

• white coat with black ears

cellular

decreased oocyte number ( J:23593 )

♀ • reduced number of oocytes in the postnatal ovary

decreased primordial germ cell number ( J:23593 )

• progressive decrease in primordial germ cells in both females and males; ~25% that of wild-type controls at E11.5 and ~10% at E12.5

• in spite of the reduced PGC number in males, normal numbers of differentiating germ cells were observed in older males, putatively due to an increase in the mitotic proliferation of spermatogonia