Phenotypes Associated with This Genotype

Genotype
MGI:3045035

• Allelic Composition: Slc6a9^tm1Jtc/Slc6a9⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:90689 )

• when the platform is removed from the water maze heterozygous mice spend more time in the former platform quadrant suggesting better retention of the platform position

nervous system

abnormal nervous system physiology ( J:90689 )

• at P1 and 12 weeks glycine uptake in brain homogenates is significantly reduced compared to wild-type

abnormal sensorimotor gating ( J:90689 )

• low concentrations of amphetamine fail to disrupt pre-pulse inhibition in heterozygous mice

abnormal NMDA-mediated synaptic currents ( J:90689 )

• perfusion with glycine or D-serine fails to increase the amplitude of NMDA receptor currents of CA1 pyramidal cells