Phenotypes Associated with This Genotype

Genotype
MGI:3044999

• Allelic Composition: Map3k4^tm1Flv/Map3k4^tm1Flv
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:90112 )

• fewer homozygotes born than anticipated

growth/size/body

decreased body size ( J:90112 )

• reduced body size of surviving homozygotes but no other obvious defects

immune system

abnormal T-helper 1 physiology ( J:90112 )

• IFN-gamma production reduced about 50% both in response to T cell receptor stimulation and to Il12/Il18 stimulation

decreased interferon-gamma secretion ( J:90112 )

• IFN-gamma production reduced about 3 fold

hematopoietic system

abnormal T-helper 1 physiology ( J:90112 )

• IFN-gamma production reduced about 50% both in response to T cell receptor stimulation and to Il12/Il18 stimulation