Phenotypes Associated with This Genotype

Genotype
MGI:3044974

• Allelic Composition: Ccnd1^tm1Dsn/Ccnd1^tm1Dsn; Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased pituitary adenoma incidence ( J:66707 )

• double homozygotes showed increased susceptibility to pituitary adenomas arising from the intermediate lobe

mortality/aging

mortality/aging ( J:66707 )

N • double homozygotes did not display premature mortality and developed normally

neoplasm

increased pituitary adenoma incidence ( J:66707 )

• double homozygotes showed increased susceptibility to pituitary adenomas arising from the intermediate lobe

behavior/neurological

abnormal reflex ( J:66707 )

• double homozygotes showed only a moderate "leg-clasping" reflex

craniofacial

craniofacial phenotype ( J:66707 )

N • double mutant mice never displayed misaligned teeth

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:66707 )

N • double homozygotes showed normal lobuloalveolar development of the mammary epithelium

increased pituitary adenoma incidence ( J:66707 )

• double homozygotes showed increased susceptibility to pituitary adenomas arising from the intermediate lobe

enlarged thymus ( J:66707 )

thymus hyperplasia ( J:66707 )

abnormal corpus luteum morphology ( J:66707 )

♀ • double homozygotes displayed an ovarian defect associated with the inability of cells forming corpus luteum to undergo a timely cell cycle exit

enlarged testis ( J:66707 )

♂

growth/size/body

increased body weight ( J:66707 )

• double homozygotes showed an increased body mass, albeit lower than that observed in single Cdkn1b mutant mice

enlarged spleen ( J:66707 )

hematopoietic system

enlarged thymus ( J:66707 )

thymus hyperplasia ( J:66707 )

enlarged spleen ( J:66707 )

immune system

enlarged thymus ( J:66707 )

thymus hyperplasia ( J:66707 )

enlarged spleen ( J:66707 )

reproductive system

abnormal corpus luteum morphology ( J:66707 )

♀ • double homozygotes displayed an ovarian defect associated with the inability of cells forming corpus luteum to undergo a timely cell cycle exit

enlarged testis ( J:66707 )

♂

female infertility ( J:66707 )

♀

vision/eye

disorganized retina layers ( J:66707 )

• despite normal retinal development, double homozygotes displayed focal disorganization of the retinal cytoarchitecture