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Phenotypes Associated with This Genotype
Genotype
MGI:3044972
Allelic
Composition		 Wt1tm1Asc/Wt1tm1Asc
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wt1tm1Asc mutation (0 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:71149 )
• death within 24 hrs after birth due to kidney defects

renal/urinary system
abnormal renal glomerulus morphology ( J:71149 )
• increase in stromal component and decrease in nephrogenic zone and number of glomerular generations
small kidney ( J:71149 )
• characterized by localized macroscopic hemorrhage

reproductive system
decreased germ cell number ( J:71149 )
• germ cells are fewer and abnormally organized
primary sex reversal ( J:71149 )
• gonads of XY mice are ovarian-like and cryptorchid

cellular
decreased germ cell number ( J:71149 )
• germ cells are fewer and abnormally organized

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory