Phenotypes Associated with This Genotype

Genotype
MGI:3044970

• Allelic Composition: Wt1^tm1Asc/Wt1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:71149 )

• death due to kidney defects within 24 hrs after birth

renal/urinary system

abnormal renal glomerulus morphology ( J:71149 )

• increase in stromal tissue and decrease in tubular epithelium

small kidney ( J:71149 )

• characterized by localized macroscopic hemorrhage

reproductive system

decreased germ cell number ( J:71149 )

• germ cells are fewer and abnormally organized

primary sex reversal ( J:71149 )

• gonads of XY mice are ovarian-like and cryptorchid

cellular

decreased germ cell number ( J:71149 )

• germ cells are fewer and abnormally organized