Analysis Tools
behavior/neurological
| N |
• male heterozygotes displayed normal locomotor activity in the elevated plus-maze test, and in a novel environment
• female heterozygotes showed normal baseline anxiety levels, stress-induced anxiety, and locomotor activity relative to wild-type
• baseline anxiety of female wild-type and heterozygous mice did not change with regard to estrous cycle phase
• female heterozygotes showed normal behavior in the dark-light emergence task, open-field and acute locomotor activity test
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• in the elevated plus-maze, heterozygous males appeared to be more anxious than wild-type males
• in the dark-light emergence and open-field tests, the anxiety level of heterozygotes was between that of homozygous null and wild-type mice
• in the elevated plus-maze, the anxious behavior of heterozygotes was indistinguishable from that of homozygous null mice
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homeostasis/metabolism
| N |
• heterozygotes displayed a normal activation of the HPA axis in response to 10 minutes of physical restraint stress
• the increased POMC1 (ACTH) and corticosterone levels produced by male or female heterozygotes did not differ from the values obtained for matched wild-type controls
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