Phenotypes Associated with This Genotype

Genotype
MGI:3044726

• Allelic Composition: Drd3^tm1Stl/Drd3^tm1Stl
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:89345 )

• homozygous mice on a high fat diet have significantly increased body fat unlike wild-type mice

increased percent body fat/body weight ( J:89345 )

♀ • female mutants on a high fat diet display a significant increase in percent body fat compared to female wild-type littermates

behavior/neurological

abnormal cued conditioning behavior ( J:43791 )

♂ • male homozygous mice display a significant preference for amphetamines at lower concentrations compared to their male wild-type littermates

increased exploration in new environment ( J:43791 )

♂ • male homozygous mice display increased activity during the first 5 minutes in a novel environment compared to male wild-type littermates

abnormal food intake ( J:89345 )

♂ • only male mutants had a detectable increase in caloric consumption on a high fat diet

hyperactivity ( J:43791 )

♂ • male homozygous mice display a greater increase in activity with low doses of cocaine compared to male wild-type littermates

growth/size/body

abnormal body water content ( J:89345 )

♂ • male mutants on a high fat diet display a significant increase in water content compared to male wild-type littermates

increased susceptibility to weight gain ( J:89345 )

♂ • male mutants on a high fat diet have a significant increase in body weight compared to male wild-type littermates or male mutants on a regular diet

homeostasis/metabolism

increased circulating leptin level ( J:89345 )

• on a high fat diet plasma leptin is significantly increased in male mutants but not in their male wild-type littermates

• plasma leptin is increased on both the normal chow and high fat diets in female mutants compared to female wild-type littermates