Mouse Genome Informatics
hm
    Wfs1tm1Yoka/Wfs1tm1Yoka
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• the number of beta cells decreases with age in homozygous mice probably as a result of increased beta cell susceptibility to apoptosis
• this effect is more prominent on a [(129/Sv x C57BL/6) x C57BL/6]F2 background than on a C57BL/6 background
• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

homeostasis/metabolism
• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age
• blood glucose levels started to rise by 16 weeks of age on a [(129/Sv x C57BL/6) x C57BL/6]F2 background but not on a C57BL/6 background
• homozygous mice developed diabetes by 36 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Wolfram Syndrome 1; WFS1 222300 J:90420