Phenotypes Associated with This Genotype

Genotype
MGI:3044688

• Allelic Composition: Ar^tm1Reb/Y; Tg(Amh-cre)8815Reb/?
• Genetic Background: involves: 129S4/SvJaeSor * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

azoospermia ( J:90393 )

♂ • mature sperm undetectable in epididymis

♂ • many highly vacuolated spermatids

endocrine/exocrine glands

decreased seminal vesicle weight ( J:90393 )

♂ • seminal vesicle reduced in weight about 20%

abnormal testis morphology ( J:90393 )

♂

abnormal seminiferous tubule morphology ( J:90393 )

♂ • normal tubules of stages I-VIII are missing

♂ • elongated spermatids absent

decreased testis weight ( J:90393 )

♂ • testis weight about 40% less than normal

abnormal Sertoli cell barrier function ( J:210656 )

• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

homeostasis/metabolism

increased circulating testosterone level ( J:90393 )

♂ • by 40X

increased circulating pituitary hormone level ( J:90393 )

♂

increased circulating follicle stimulating hormone level ( J:90393 )

♂ • by 2X

increased circulating luteinizing hormone level ( J:90393 )

♂ • by 23X

reproductive system

azoospermia ( J:90393 )

♂ • mature sperm undetectable in epididymis

♂ • many highly vacuolated spermatids

decreased seminal vesicle weight ( J:90393 )

♂ • seminal vesicle reduced in weight about 20%

abnormal testis morphology ( J:90393 )

♂

abnormal seminiferous tubule morphology ( J:90393 )

♂ • normal tubules of stages I-VIII are missing

♂ • elongated spermatids absent

decreased testis weight ( J:90393 )

♂ • testis weight about 40% less than normal

abnormal Sertoli cell barrier function ( J:210656 )

• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction