Mouse Genome Informatics
hm
    Amacrtm1Jkh/Amacrtm1Jkh
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 1 in 7 homozygous mice die after 9 days on a phytol supplemented diet

adipose tissue
• after 6 weeks on a phytol supplemented diet the fatpads in homozygous mice are 62% smaller than in homozygous mice on a normal chow diet

growth/size/body
• after 6 weeks on a phytol supplemented diet the fatpads in homozygous mice are 62% smaller than in homozygous mice on a normal chow diet
• after 6 weeks on a phytol supplemented diet homozygous mice weigh 10% less than wild-type mice while no weight difference is detected on a normal chow diet

homeostasis/metabolism
• cholesterol concentrations are about 50% lower on either a normal chow diet or a phytol supplemented diet in homozygous mice compared to wild-type mice
• after 6 weeks on a phytol supplemented diet serum alkaline phosphatase levels areincreased 175% in homozygous mice compared to wild-type mice
• after 6 weeks on a phytol supplemented diet homozygous mice had decreased palmitic, oleic, and stearic acid concentrations
• after 6 weeks on a phytol supplemented diet homozygous mice had increased phytanic and pristanic acid concentrations
• after 6 weeks on a phytol supplemented diet triacylglycerols are reduced 52% in homozygous mice compared to wild-type mice

liver/biliary system
• after 6 weeks on a phytol supplemented diet liver size increases to a great extent in homozygous mice compared to wild-type mice
• after 6 weeks on a phytol supplemented diet livers of homozygous mice display accumulation of lymphocytes and Kupffer's cells, multivacuolar degeneration, and coagulation necrosis
• proliferation of enlarged and unevenly shaped smooth endoplasmic reticulum and peroxisomes is also seen
• the concentration of C24 bile acid species is reduced and the concentration of C27 bile acid precursors is increased 100 - 200 times

Mouse Models of Human Disease
OMIM IDRef(s)
Alpha-Methylacyl-Coa Racemase Deficiency; AMACRD 614307 J:90370