Phenotypes Associated with This Genotype

Genotype
MGI:3044363

• Allelic Composition: Tg(ACTB-HSF1)1Anak/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

arrest of male meiosis ( J:61442 )

♂ • spermatogenesis arrested at pachytene stage

♂ • apoptosis in seminiferous tubules was common

abnormal male reproductive system morphology ( J:61442 )

♂

small seminiferous tubules ( J:61442 )

♂ • diameter of seminiferous tubules reduced about 20-30%

decreased testis weight ( J:61442 )

♂ • testis weight about 42% of control weight

male infertility ( J:61442 )

♂ • only males are infertile

endocrine/exocrine glands

small seminiferous tubules ( J:61442 )

♂ • diameter of seminiferous tubules reduced about 20-30%

decreased testis weight ( J:61442 )

♂ • testis weight about 42% of control weight

cellular

arrest of male meiosis ( J:61442 )

♂ • spermatogenesis arrested at pachytene stage

♂ • apoptosis in seminiferous tubules was common