Mouse Genome Informatics
ht
    Apptm1Ini/App+
involves: C57BL/6 * CBA * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• moderately accelerated mortality among females only after 56 weeks of age
• by 125 weeks of age survival was about 48.5% as opposed to 62.2% in controls

behavior/neurological
• slower at a water finding test at 27 months of age, no difference when tested at 6 months of age
• females were slower at spatial memory acquisition
• males were quicker to begin exploration in open field tests
• overall locomotor activity was increased in males

nervous system
• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form
• no signs of neuritic plaque or neurofibrillar tangle formation

homeostasis/metabolism
• the abundance of the longer form of beta amyloid was significantly increased relative to the shorter form

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:90296