Phenotypes Associated with This Genotype

Genotype
MGI:3043880

• Allelic Composition: Mlxipl^tm1Kuy/Mlxipl^tm1Kuy
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:89865 )

• on a 70% sucrose diet homozygous mice die in less than 1 week

• on a high-fructose diet homozygous mice die within a few days

• on a standard chow diet homozygous mice have a normal life span

cellular

asthenozoospermia ( J:324060 )

♂

immotile sperm ( J:324060 )

♂

growth/size/body

increased liver weight ( J:89865 )

• on a high starch diet liver weight are about 40% greater in homozygous mice compared to wild-type mice probably as a result of increased glycogen stores in homozygous mice

adipose tissue

decreased brown adipose tissue amount ( J:89865 )

• on a standard diet homozygous mice have lower brown fat weights

decreased white adipose tissue amount ( J:89865 )

decreased epididymal fat pad weight ( J:89865 )

• on a standard diet homozygous mice have lower epididymal fat weights

homeostasis/metabolism

decreased body temperature ( J:89865 )

• on a 70% sucrose diet homozygous mice develop hypothermia

abnormal glucose homeostasis ( J:89865 )

increased circulating glucose level ( J:89865 )

• plasma glucose levels are somewhat elevated

increased circulating insulin level ( J:89865 )

• plasma insulin levels are somewhat elevated

• on a high-starch diet plasma insulin levels increase significantly compared to homozygous mice on a standard diet or wild-type mice on either diet

increased liver glycogen level ( J:89865 )

• liver glycogen levels are elevated but muscle glycogen levels are not elevated

• liver glycogen levels are elevated further on a high-starch diet

insulin resistance ( J:89865 )

• on a high-starch diet homozygous mice are moderately insulin resistant

abnormal lipid homeostasis ( J:89865 )

decreased circulating cholesterol level ( J:89865 )

• on a high starch diet plasma cholesterol is significantly lower compared to wild-type mice on the same diet

decreased fatty acids level ( J:89865 )

• hepatic fatty acid synthesis rates are 65% lower in homozygous mice

decreased circulating free fatty acids level ( J:89865 )

• on either a standard or high-starch diet plasma free fatty acid levels are about 50% that in wild-type mice on the same diet

• on a 70% sucrose diet free fatty acid levels decline further in homozygous mice

reproductive system

asthenozoospermia ( J:324060 )

♂

immotile sperm ( J:324060 )

♂

male infertility ( J:324060 )

♂

liver/biliary system

increased liver weight ( J:89865 )

• on a high starch diet liver weight are about 40% greater in homozygous mice compared to wild-type mice probably as a result of increased glycogen stores in homozygous mice

increased liver glycogen level ( J:89865 )

• liver glycogen levels are elevated but muscle glycogen levels are not elevated

• liver glycogen levels are elevated further on a high-starch diet

abnormal liver physiology ( J:89865 )

• hepatic glucose levels are increased

• hepatic pyruvate/phosphoenolpyruvate ratio is decreased indicating inhibition of hepatic glycolysis