Phenotypes Associated with This Genotype

Genotype
MGI:3043793

• Allelic Composition: Runx2^tm1Ldq/Runx2⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in trabecular and cortical thickness in Runx2^tm1Ldq/Runx2⁺ and Runx2^tm1Ldq/Runx2^tm1Ldq tibia

growth/size/body

decreased birth body size ( J:89822 )

• newborn heterozygotes have significantly lower body weights and lengths compared to wild-type littermates but are larger than homozygous mutants

decreased birth weight ( J:89822 )

limbs/digits/tail

abnormal tibia morphology ( J:89822 )

• trabecular bone volume/tissue volume and trabecular thickness are significantly reduced in heterozygous mice compared to wild-type mice

• no other gross skeletal abnormalities were detected in heterozygous mice

skeleton

abnormal tibia morphology ( J:89822 )

• trabecular bone volume/tissue volume and trabecular thickness are significantly reduced in heterozygous mice compared to wild-type mice

• no other gross skeletal abnormalities were detected in heterozygous mice

abnormal trabecular bone morphology ( J:89822 )

• trabecular bone volume/tissue volume and trabecular thickness are significantly reduced in heterozygous mice compared to wild-type mice