Phenotypes Associated with This Genotype

Genotype
MGI:3043788

• Allelic Composition: Npc1l1^tm1Swa/Npc1l1^tm1Swa
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased intestinal cholesterol absorption ( J:89712 )

• homozygous mice absorbed 69% less dietary cholesterol than controls

• unlike wild-type mice dietary supplementation with cholic acid did not increase cholesterol absorption

• treatment of homozygous mice with ezetimibe did not lower absorption levels further

abnormal cholesterol level ( J:89712 )

• reduced cholesterol ester level in the liver

• however, no significant differences are detected in liver free cholesterol or triglyceride levels or in plasma cholesterol or triglycerides levels

digestive/alimentary system

decreased intestinal cholesterol absorption ( J:89712 )

• homozygous mice absorbed 69% less dietary cholesterol than controls

• unlike wild-type mice dietary supplementation with cholic acid did not increase cholesterol absorption

• treatment of homozygous mice with ezetimibe did not lower absorption levels further