Phenotypes Associated with This Genotype

Genotype
MGI:3043421

• Allelic Composition: Retn^tm1Laz/Retn^tm1Laz
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:90033 )

N • the size and distribution of adipose depots is normal in homozygotes

homeostasis/metabolism

decreased circulating glucose level ( J:90033 )

• blood glucose levels after 4 ? 6 hours of or overnight fasting are significantly lower homozygotes compared to weight matched wild-type mice

• during constant hyperinsulinemia homozygotes require more glucose to maintain a constant glucose level primarily because of decreased glucose production

• administration of pyruvate does not increase blood glucose levels in homozygotes as much as in wild-type mice suggesting impaired gluconeogenesis

improved glucose tolerance ( J:90033 )

• on a high-fat diet glucose tolerance is significantly better in homozygotes compared to wild-type mice

decreased liver triglyceride level ( J:90033 )

• hepatic triglyceride levels tend to be lower in homozygotes

liver/biliary system

decreased liver triglyceride level ( J:90033 )

• hepatic triglyceride levels tend to be lower in homozygotes