Phenotypes Associated with This Genotype

Genotype
MGI:3043296

• Allelic Composition: Mapt^{tm1(Mecp2)Jae}/Mapt^{tm1(Mecp2)Jae}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:89593 )

N • no premature death is seen in homozygotes

behavior/neurological

excessive scratching ( J:89593 )

• lesions are seen by 9 months probably as a result of excessive scratching

tremors ( J:89593 )

ataxia ( J:89593 )

• gait ataxia is seen in homozygous mutants

impaired balance ( J:89593 )

• homozygotes display side-to-side swaying

abnormal sexual interaction ( J:89593 )

• homozygotes do not mate

growth/size/body

cachexia ( J:89593 )

• by 9 months homozygotes appear emaciated

postnatal growth retardation ( J:89593 )

• by weaning homozygotes are 60% smaller than wild-type littermates probably as a result of an inability to compete for food

• after weaning homozygotes remain smaller than wild-type littermates

vision/eye

cataract ( J:89593 )

• by 9 months homozygotes have developed cataracts

integument

disheveled coat ( J:89593 )

• by 9 months homozygotes appear disheveled