Phenotypes Associated with This Genotype

Genotype
MGI:3042780

• Allelic Composition: Fkbp8^tm1Tili/Fkbp8^tm1Tili; Shh^tm1Chg/Shh^tm1Chg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal dorsal-ventral axis patterning ( J:89364 )

• there is a general ventralization of neural cell fates in cells posterior to the prospective spinal cord similar to that seen in Fkbp8^tm1Tili homozygotes

abnormal neural tube morphology ( J:89364 )

• at E12.5 double homozygotes have dilated caudal neural tubes similar to Fkbp8^tm1Tili homozygotes

absent notochord ( J:89364 )

abnormal somite shape ( J:89364 )

• by E12.5 the somites in double homozygotes are abnormally shaped similar to Shh^tm1Chg homozygotes

decreased somite size ( J:89364 )

• by E12.5 the somites in double homozygotes are small similar to Shh^tm1Chg homozygotes

limbs/digits/tail

abnormal limb morphology ( J:89364 )

• by E12.5 the limbs fail to grow out along the proximodistal axis similar to Shh^tm1Chg homozygotes

vision/eye

microphthalmia ( J:89364 )

• double homozygotes are rescued from cyclopia seen in Shh^tm1Chg homozygotes

nervous system

abnormal neural tube morphology ( J:89364 )

• at E12.5 double homozygotes have dilated caudal neural tubes similar to Fkbp8^tm1Tili homozygotes