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Phenotypes Associated with This Genotype
Genotype
MGI:3042292
Allelic
Composition
GhSma1/Gh+
Genetic
Background
C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GhSma1 mutation (0 available); any Gh mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• the percent body white fat is significantly increased in heterozygotes compared to wild-type mice at 5 to 6 months of age

endocrine/exocrine glands
• the anterior lobe of the pituitary gland lacks acidophilic cells in heterozygotes
• the anterior lobe of the pituitary gland is disproportionately smaller than the posterior lobe
• the pituitary gland is smaller in size at 3 months in heterozygotes compared to wild-type mice
• the pituitary gland is of reduced weight at 3 months in heterozygotes compared to wild-type mice

growth/size/body
• heterozygous mice undergo a reduced peripubertal growth spurt resulting in a significant difference in body weight compared to wild-type mice by 12 weeks of age
• the heart, spleen, and paired kidneys are proportionally smaller in relation to body mass in mutants at 3 months in mutants compared to wild-type mice
• the reduction in body size is not as severe as in homozygous mutants

liver/biliary system
• liver mass is disproportionately smaller in relation to body mass at 3 months in heterozygotes compared to wild-type mice

reproductive system
• median litter size at weaning is reduced in crosses between heterozygotes compared to crosses between wild-type mice
• maximal litter size is decreased in crosses involving female heterozygotes

nervous system
• the anterior lobe of the pituitary gland lacks acidophilic cells in heterozygotes
• the anterior lobe of the pituitary gland is disproportionately smaller than the posterior lobe
• the pituitary gland is smaller in size at 3 months in heterozygotes compared to wild-type mice
• the pituitary gland is of reduced weight at 3 months in heterozygotes compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Isolated Growth Hormone Deficiency, Type II; IGHD2 173100 J:89518


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory