Mouse Genome Informatics
involves: 129 * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in 1 year old animals, a 50-80% reduction in the size of fat deposits was noted; increasing severity with age

• impaired learning ability; mice took 7 times longer to find a submerged platform in a water filled chamber after several trials
• mice had impaired ability to remain on a rotating stick compared to controls

• animals are 10% smaller than controls
• reduced weight on regular diet; on high fat diet, mice gained significantly less weight than controls
• animals are 14% shorter than controls

• elevated fasting glucose levels
• elevated fasting insulin level
• serum concentration was reduced by 50% at 20 weeks of age in mice on a normal diet; on high fat diet, serum leptin concentrations remained unchanged or lower, while control mice had significantly higher leptin concentrations
• lower muscle glycogen concentration in homozygous mice

reproductive system
• no pups were produced from matings including hemizygous males

Mouse Models of Human Disease
Coffin-Lowry Syndrome; CLS 303600 J:67575 , J:83536