Mouse Genome Informatics
involves: 129 * C57BL/6
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
adipose tissue
• in 1 year old animals, a 50-80% reduction in the size of fat deposits was noted; increasing severity with age (J:83536)

• impaired learning ability; mice took 7 times longer to find a submerged platform in a water filled chamber after several trials (J:67575)
• mice had impaired ability to remain on a rotating stick compared to controls (J:67575)

• animals are 10% smaller than controls (J:67575)
• reduced weight on regular diet; on high fat diet, mice gained significantly less weight than controls (J:83536)
• animals are 14% shorter than controls (J:67575)

• elevated fasting glucose levels (J:83536)
• elevated fasting insulin level (J:83536)
• serum concentration was reduced by 50% at 20 weeks of age in mice on a normal diet; on high fat diet, serum leptin concentrations remained unchanged or lower, while control mice had significantly higher leptin concentrations (J:83536)
• lower muscle glycogen concentration in homozygous mice (J:67575)

reproductive system
• no pups were produced from matings including hemizygous males (J:83536)

Mouse Models of Human Disease
Coffin-Lowry Syndrome; CLS 303600 J:67575 , J:83536