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Phenotypes Associated with This Genotype
Genotype
MGI:3042187
Allelic
Composition		 Amhr2tm1Bhr/Amhr2tm1Bhr
Inhatm1Bay/Inhatm1Bay
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm1Bhr mutation (0 available); any Amhr2 mutation (27 available)
Inhatm1Bay mutation (0 available); any Inha mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:36027 )
• multifocal Sertoli/granulosa cell tumors
increased granulosa cell tumor incidence ( J:36027 )
• multifocal granulosa cell tumors
increased testis tumor incidence ( J:36027 )
• testicular tumors, larger than those observed in Inha-deficient mice
increased Leydig cell tumor incidence ( J:36027 )
• Leydig cell neoplasia

reproductive system
increased granulosa cell tumor incidence ( J:36027 )
• multifocal granulosa cell tumors
increased testis tumor incidence ( J:36027 )
• testicular tumors, larger than those observed in Inha-deficient mice
increased Leydig cell tumor incidence ( J:36027 )
• Leydig cell neoplasia
dilated uterus ( J:36027 )
• the uteri observed in male pseudohermaphrodites were dilated and fluid-filled

endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:36027 )
• multifocal granulosa cell tumors
increased testis tumor incidence ( J:36027 )
• testicular tumors, larger than those observed in Inha-deficient mice
increased Leydig cell tumor incidence ( J:36027 )
• Leydig cell neoplasia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory