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Phenotypes Associated with This Genotype
Genotype
MGI:3042182
Allelic
Composition
Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm1Bhr mutation (0 available); any Amhr2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• observed in areas of focal seminiferous tubule degeneration
• observed in areas of focal seminiferous tubule degeneration
• focal atrophy of the germinal epithelium by 2 months of age

reproductive system
N
• female mice developed, exhibited normal folliculogenesis and germ cell development, and were fertile
• observed in areas of focal seminiferous tubule degeneration
• observed in areas of focal seminiferous tubule degeneration
• focal atrophy of the germinal epithelium by 2 months of age
• males developed Mullerian duct derivatives, including a uterus, oviducts, and a partial vagina that were superimposed upon the male reproductive system
• male mice had testes of normal size that were properly descended into the scrotal sac
• normal differentiation of male-specific Wolffian duct-derived tissue
• spermatogenesis was unimpaired and sperm was produced, however some males were infertile due to the presence of female reproductive organs that blocked sperm transfer
• some male mice sired offspring, however fewer litters relative to controls

embryo

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
persistent Mullerian duct syndrome DOID:0050791 OMIM:261550
J:171430


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory