Phenotypes Associated with This Genotype

Genotype
MGI:3042112

• Allelic Composition: Arnt^tm1Bra/Arnt^tm1Bra
• Genetic Background: B6.129-Arnt^tm1Bra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:89470 )

• partial embryonic lethality is seen

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:89470 )

• homozygous mice are resistant to TCDD induced hepatotoxicity and thymic involution

• however, induction of Cyp1a1 and Cyp1a2 ethoxyresorufin O-deethylase activity is not impaired

reproductive system

female infertility ( J:89470 )

♀ • homozygous females are unable to maintain pregnancy

♀ • homozygous males are fertile