Phenotypes Associated with This Genotype

Genotype
MGI:3042021

• Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal active avoidance behavior ( J:89788 )

• mutant mice learn the task significantly faster than wild-type mice

abnormal passive avoidance behavior ( J:89788 )

• mutants have significantly better long term retention (longer step through latencies at 24 hours after training) than wild-type mice

increased locomotor activity ( J:89788 )

• mutant mice have a tendency to be more active in the open field than wild-type mice

nervous system

reduced long-term potentiation ( J:89788 )

• the long term potentiation induced by theta burst stimulation is significantly smaller in mutants than in wild-type mice

cellular

cellular phenotype ( J:162580 )

N • Background Sensitivity: mouse embryonic fibroblasts (MEFs) exhibit normal proliferation unlike MEFs from mice on a CD-1 background

muscle

muscle phenotype ( J:190460 )

N • at 2 months, mice exhibit normal skeletal muscle tissue