Phenotypes Associated with This Genotype

Genotype
MGI:3042020

• Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:124903 )

hematopoietic system

decreased T cell proliferation ( J:58468 )

• there is a 80 - 90% decrease in thymocyte proliferation following T cell receptor activation in mutants compared to wild-type mice

decreased T cell number ( J:58468 )

• reduced numbers of single positive mature T cells are seen in mutants compared to wild-type mice however, thymus cellularity is unaffected

immune system

decreased T cell proliferation ( J:58468 )

• there is a 80 - 90% decrease in thymocyte proliferation following T cell receptor activation in mutants compared to wild-type mice

decreased T cell number ( J:58468 )

• reduced numbers of single positive mature T cells are seen in mutants compared to wild-type mice however, thymus cellularity is unaffected

cardiovascular system

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

• mice show no reduction in exercise-induced (swimming) cardiac hypertrophy compared to that seen in wild-type mice

cellular

decreased T cell proliferation ( J:58468 )

• there is a 80 - 90% decrease in thymocyte proliferation following T cell receptor activation in mutants compared to wild-type mice

growth/size/body

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

• mice show no reduction in exercise-induced (swimming) cardiac hypertrophy compared to that seen in wild-type mice