Phenotypes for Nr1h2 MGI:3041858 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nr1h2^tm1Djm/Nr1h2^tm1Djm
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h2^tm1Djm mutation (3 available); any Nr1h2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

thin epidermis ( J:89874 )

• the epidermis of mutant mice is thinner with fewer proliferating cells in the basal layer compared to wild-type littermates

• treatment with oxysterol does not result in thickening of the epidermis unlike in wild-type littermates and Nr1h3^tm1Djm homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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