Phenotypes Associated with This Genotype

Genotype
MGI:3041527

• Allelic Composition: Prkar1b^tm1Gsm/Prkar1b^tm1Gsm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:30405 )

N • normal exploratory behavior in open field test

N • no differences in leaning, defecation, rearing, or grooming

N • normal spatial reference memory in Barnes maze task

N • normal spatial learning in Morris water maze

N • normal context conditioning

N • normal cued conditioning

nervous system

nervous system phenotype ( J:28735 , J:30405 )

N • normal LTP in Schaffer collateral-CA1 synapse (J:28735)

N • gross neural anatomy of hippocampus appeared normal (J:28735)

N • normal LTP in response to forskolin (J:30405)

reduced long-term potentiation ( J:30405 )

• decreased in mossy fiber pathways

reduced long-term depression ( J:28735 )

• with associated inability to maintain stable depotentiation at the Schaffer collateral-CA1 synapse and lateral perforant path-dentate granule cell synapse