Phenotypes Associated with This Genotype

Genotype
MGI:3041124

• Allelic Composition: Nkx2-5^tm2Siz/Nkx2-5⁺
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal impulse conducting system morphology ( J:89216 )

• form a smaller central conduction system, with smaller atrioventricular node and His bundle

• the number of cells in the conduction system is reduced by approximately half

abnormal Purkinje fiber morphology ( J:89216 )

• hypocellularity of the peripheral Purkinje network

abnormal atrioventricular node morphology ( J:89216 )

• smaller atrioventricular node

abnormal heart development ( J:89216 )

heart block ( J:89216 )

• defects in in the atrioventricular node, His bundle, and intraventricular conduction

• exhibit similar conduction and electrophysiologic abnormalities as heterozygous Nkx2-5^tm1Siz mice

muscle

abnormal impulse conducting system morphology ( J:89216 )

• form a smaller central conduction system, with smaller atrioventricular node and His bundle

• the number of cells in the conduction system is reduced by approximately half

abnormal Purkinje fiber morphology ( J:89216 )

• hypocellularity of the peripheral Purkinje network

abnormal atrioventricular node morphology ( J:89216 )

• smaller atrioventricular node